Idra-21 Kognitivni prahje pozitiven alosterični regulator receptorja AMPA in derivat benzotiadiazola. Je kiralna molekula, v kateri je ( plus ) - IDRA-21 aktivna oblika.
Kako se je IDRA-21 obnašal v poskusih na živalih?
V študiji spodbujanja inteligence pri živalih,IDRA-21 prahbistveno izboljšala sposobnost učenja in spomina. Pri odpravljanju kognitivnih primanjkljajev, ki jih povzroča dolgotrajna-uporaba alprazolama ali skopolamina, je približno 10-30-krat močnejši od aniracetama. Najbolj neverjetna stvar je njegov čas presnove zdravil: preučevali so trajne učinke, ki trajajo do 48 ur po enkratnem dajanju. Raziskovalci pravijo, da je mehanizem tega učinka verjetno skozi spodbujanje dolgoročne izboljšave med možganskimi sinapsami.
Kakšen je proces raziskovanja zdravil za izboljšanje kognitivnih sposobnosti? Kako je biloIDRA-21Rojen?
In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.